Branched peptide linkers

Details Branched peptide linkers Branched peptide linkers

C - Chemistry, Metallurgy

07

K

C07K 4/00 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2264610

Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of being bonded to the branched linkers varies by a factor of two for each generation of branching.

La présente invention concerne des conjugués contenant un ligand ciblé tel qu'un anticorps, un médicament thérapeutiquement actif, et une séquence de liaison peptidique ramifiée. Cette séquence de liaison peptidique ramifiée contient au moins deux fractions acide aminé qui constituent un site de clivage d'enzyme. Le nombre de médicaments qu'il est possible de lier aux séquences de liaison ramifiées est multiplié par 2 à chaque génération de ramification.

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