Branched polyalkylene glycols

Details Branched polyalkylene glycols Branched polyalkylene glycols

C - Chemistry, Metallurgy

07

K

C07K 17/08 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 21/00 (2006.01) C07K 14/555 (2006.01) C07K 17/00 (2006.01) C08G 65/329 (2006.01) C08G 65/337 (2006.01)

Patent

CA 2395254

The present invention provides branched polyalkylene glycols useful as a chemically modifying agent for physiologically active polypeptides, wherein two single-chain polyalkylene glycols are linked to a group having a cyclic structure other than a plane structure, and wherein a group having reactivity with an amino acid side chain, an N-terminal amino group or a C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity is linked to the group having a structure other than a plane structure.

L'invention concerne des glycols de polyalkylène ramifiés utilisés comme réactifs dans la modification chimique de polypeptides actifs sur le plan physiologique, deux glycols de polyalkylène à chaîne unique étant attachés à un groupe doté d'une structure cyclique différente d'une structure plane et à un groupe réactif à chaîne latérale d'acides aminés, au groupe aminé N-terminal ou au groupe de carboxyle C-terminal dans un polypeptide ou à un groupe qui peut être converti en un tel groupe réactif.

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