Branched polyanhydrides

Details Branched polyanhydrides Branched polyanhydrides

C - Chemistry, Metallurgy

08

G

C08G 67/04 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/58 (2006.01) C08F 20/08 (2006.01) C08F 122/04 (2006.01) C08L 73/02 (2006.01)

Patent

CA 2083161

Branched polyanhydrides that have superior pro- perties for use in the controlled delivery of substances, prepared by the polymerization of a dicarboxylic acid monomer and a branching agent. The branching agent is a polycarboxylic acid monomer such as 1,3,5-benzen- etricarboxylic acid ("BTC"), or an oligomerized fatty acid trimer. Alternatively, the branching agent is a poly- carboxylic acid polymer such as poly(acrylic acid) ("PAA"). These branched polymers have significantly higher molecular weights and lower specific viscosity than linear polymers prepared under similar conditions. A major advantage of branched polyanhydrides is that the degradation and release kinetics can be substantial- ly altered without significantly changing the physical properties of the polymer relative to the corresponding linear polymer. By manipulating both the diacid and the branching agent, a wide variety of biodegradable controlled delivery devices for diverse applications can be prepared.

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