Branched polymers and their conjugates

Details Branched polymers and their conjugates Branched polymers and their conjugates

C - Chemistry, Metallurgy

08

G

C08G 65/329 (2006.01) A61K 47/48 (2006.01) C07K 17/08 (2006.01) C08G 65/332 (2006.01)

Patent

CA 2466027

The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, -O-alkylene-O-, -alkylene-O-alkylene-, -aryl-O-, -O- aryl-, (-O-alkylene-)m, or (-alkylene-O-)m linkage, wherein m is 1-10.

L'invention concerne des polymères hydrosolubles réactifs ramifiés contenant au moins deux branches polymères, tels que le poly(éthylène glycol), fixés sur une molécule à noyau hydrocarboné aliphatique centrale, par l'intermédiaire de liaisons hétéroatomes. Les polymères ramifiés selon l'invention comportent au moins un groupe fonctionnel destiné à réagir avec un agent biologiquement actif, de sorte à former un conjugué biologiquement actif. Le groupe fonctionnel du polymère ramifié peut être fixé sur le noyau hydrocarboné aliphatique directement ou par l'intermédiaire d'une liaison interposée, telle qu'une liaison hétéroatome, -alkylène-, -O-alkylène-O-, -alkylène-O-alkylène-, -aryl-O-, -O-aryl-, (-O-alkylène-)¿m? ou (-alkylène-O-)¿m?, m étant compris entre 1 et 10.

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