Branched synthetic peptide conjugate

Details Branched synthetic peptide conjugate Branched synthetic peptide conjugate

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 47/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2191862

The invention is a branched synthetic peptide conjugate which can be designated to bind to a target cell surface receptor, to penetrate into target cells, and to deliver a diagnostic probe or cytotoxic functionality to a desired site of action. The invention provides a relatively small molecule of flexible design having a branched structure for systematically incorporating a desired number of cytotoxic functions, peptide-based localization signals or diagnostic probes. The invention addresses problems associated with protein- based therapeutic or diagnostic agents.

L'invention concerne un peptide ramifié de synthèse utilisé comme ligand capable de se fixer sur des récepteurs à la surface de cellules cibles, de pénétrer à l'intérieur de cellules cibles et d'introduire une sonde pour diagnostic ou une entité cytotoxique au site d'action souhaité. L'invention porte sur une molécule qui est relativement petite et de structure modulable et ramifiée, à laquelle on peut adjoindre différentes entités cytotoxiques, signaux peptidiques de localisation ou sondes pour diagnostic. L'invention facilite l'utilisation d'agents pour diagnostic ou à usage thérapeutique basés sur des protéines.

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