Brca1 associated protein (bap-1) and uses therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/57 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2262479

Nucleic acid and amino acid sequences of a BRCA1 Associated Protein, BAP-1, are provided. These sequences, the protein, and anti-BAP-1 antibodies are useful in therapeutics and diagnostics for cancers associated with loss of the 3p21 chromosomal region and/or inappropriate BAP-1 levels.

La présente invention concerne des séquences d'acides nucléiques et d'acides aminés de la protéine BAP-1 associée à la BRCA1. Ces séquences, la protéine, et les anticorps anti-BAP-1 conviennent comme agents thérapeutiques et de diagnostic pour des cancers associés à la perte de la région chromosomique 3p21 et/ou des niveaux inadaptés de BAP-1.

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