C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2259154
Disclosed are methods and compositions relating to the diagnosis and treatment of breast and related cancers. Compositions and methods for the detection of the BRCA1 gene product in vivo and in vitro are disclosed, as well as methods for diagnosing aberrant localization of BRCA1 protein in cells using anti- BRCA1 antibodies. Also disclosed are methods for identifying BRCA1-associated proteins which function in the proper translocation of the BRCA1 gene product to the cell nucleus.
L'invention concerne des procédés et des compositions s'appliquant au diagnostic et au traitement du cancer du sein et autres cancers apparentés. L'invention concerne également des compositions et des procédés de détection du produit génique BRCA1 in vivo et in vitro, ainsi que des procédés de diagnostic de localisation aberrante de la protéine BRCA1 dans des cellules mettant en oeuvre des anticorps anti-BRCA1. L'invention concerne de plus des procédés d'identification des protéines associées à BRCA1 qui agissent dans la translocation correcte du produit génique BRCA1 vers le noyau cellulaire.
Allred D. Craig
Chen Chi-Fen
Chen Phang-Lang
Chen Yumay
Farmer Andrew A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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