Brca1 mrna expression predicts survival in patients with...

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G01N 33/574 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2717670

The invention relates to methods for predicting the clinical outcome of a patient which suffers from bladder cancer based on the expression levels of BRCA1 wherein high BRCA1 expression levels are indicative of a poor prognosis. Moreover, the invention relates to methods for predicting the response to chemotherapy of a patient which suffers from bladder cancer based on the expression levels of BRCA1, in particular, in patients which have been treated with chemotherapy prior to surgical removal of the tumor.

L'invention concerne des procédés de prédiction de résultat clinique d'un patient souffrant d'un cancer de la vessie fondée sur les niveaux d'expression de BRCA1, des niveaux d'expression de BRCA1 élevés indiquant un pronostic défavorable. De plus, cette invention concerne des procédés de prédictions de réponse à une chimiothérapie d'un patient qui souffre d'un cancer de la vessie fondées sur les niveaux d'expression de BRCA1, en particulier chez des patients qui ont été traités par chimiothérapie avant l'extraction chirurgicale de la tumeur.

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