Breast cancer related gene znfn3a1

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2599337

Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. Also described are methods of treating and preventing breast cancer and breast cancer metastasis as well as methods of assessing the prognosis of a breast cancer subject and the efficacy of a breast cancer therapy. In one embodiment, the diagnostic method involves determining the expression level of ZNFN3A1, a gene whose expression is markedly elevated in breast cancers, that therefore can be used to discriminate between BRC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of BRC, methods of treating BRC and method for vaccinating a subject against BRC.

L~invention concernée décrit des procédés objectifs de détection et de diagnostic du cancer du sein (BRC). Les procédés de traitement et de prévention du cancer du sein ainsi que des métastases du cancer du sein sont également décrits, les procédés d~évaluation du pronostic d~un sujet atteint de ce cancer et l~efficacité du traitement contre le cancer du sein. Dans un mode de réalisation, le procédé de diagnostic implique la détermination du niveau d~expression du ZNFN3A1, un gène dont l~expression est nettement élevée lors d~un cancer du sein ; il peut donc être utilisé pour différencier les cellules BRC des cellules normales. La présente invention concerne également des procédés de criblage pour les agents thérapeutiques qui se révèlent utiles dans le traitement du BRC, des procédés de traitement du BRC et des procédés destinés à vacciner un sujet contre le BRC.

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