Breast cancer therapy based on hormone receptor status with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/51 (2006.01) A61K 31/337 (2006.01) A61K 47/42 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2672618

The present invention relates to methods and kits for the treatment of breast cancer based on hormone receptor status of progesterone receptor and estrogen receptor comprising the administration of a taxane alone, in combination with at least one other and other therapeutic agents, as well as other treatment modalities useful in the treatment of breast cancer. In particular, the invention relates to the use of nanoparticles comprising paclitaxel and albumin (such as Abraxane®) either alone or in combination with other chemotherapeutic agents or radiation, which may be used for the treatment of breast cancer which does not express estrogen receptor and/or progesterone receptor.

La présente invention concerne des procédés et des trousses destinés au traitement du cancer du sein fondés sur le statut des récepteurs hormonaux du récepteur de la progestérone et du récepteur de l'oestrogène, les procédés consistant à administrer du taxane seul ou conjointement à au moins un ou plusieurs autres agents thérapeutiques. L'invention concerne également d'autres modalités de traitement utiles dans le traitement du cancer du sein. L'invention concerne plus particulièrement l'utilisation de nanoparticules comprenant du paclitaxel et de l'albumine (telle que l'Abraxane®) seules ou conjointement à d'autres agents chimiothérapeutiques ou à des radiations. La présente invention peut être utilisée pour le traitement du cancer du sein qui n'exprime pas le récepteur de l'oestrogène et/ou le récepteur de la progestérone.

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