C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 1/00 (2006.01) C07K 16/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2510314
Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
L'invention concerne des séquences de gènes liés au cancer, des séquences d'acides aminés dérivées, ainsi que des méthodes de dosage d'agents antitumoraux potentiels basés sur la modulation de l'expression desdits gènes liés au cancer. L'invention porte également sur des anticorps qui réagissent avec les polypeptides décrits et sur des méthodes d'utilisation des anticorps pour le traitement d'états cancéreux, par exemple au moyen de l'anticorps pour le ciblage de cellules cancéreuses in vivo en vue de la libération d'agents thérapeutiques dans celles-ci. L'invention se rapporte également à des méthodes de diagnostic au moyen de ces séquences de gènes.
Ebner Reinhard
Rieger Michael
Weigle Bernd
Avalon Pharmaceuticals Inc.
Smart & Biggar
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