G - Physics
01
N
G01N 33/497 (2006.01) C12Q 1/25 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2468858
A method of assessing the state of the lining of the small intestine in a mammal or human injesting a suitable labelled test substrate which requires conversion by a brush border enzyme for transport across the small intestinal lining. Suitable substrates include sucrose and maltose. The transport of these can very conveniently be measured by assessing the amount of label present in carbon dioxide expelled in the breath after a period of time. It has been shown that this method has application to assessing damage cause by chemotherapeutic induced mucositis as well as gastroenteritis with an infectious cause.
Procédé pour évaluer l'état de la muqueuse de l'intestin grêle chez un mammifère ou un humain par l'injection d'un substrat de test dûment étiqueté, qui nécessite la conversion par l'enzyme de bordure en brosse à des fins de transport à travers la muqueuse de l'intestin grêle. Les substrats appropriés comprennent le sucrose et le maltose. Ce transport peut être mesuré par l'estimation de la quantité de l'étiquette présente dans le dioxyde de carbone expiré dans l'haleine après une période donnée. Il a été démontré que ce procédé peut s'appliquer pour estimer le dommage d'une mucite provoquée par la chimiothérapie ainsi que la gastro-entérite d'origine infectieuse.
Butler Ross
Davidson Geoffrey
Pelton Nicole
Tivey David
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Children Youth And Women's Health Service Incorporated
Women's And Children's Hospital
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