Bridged catharanthus alkaloid dimers

Details Bridged catharanthus alkaloid dimers Bridged catharanthus alkaloid dimers

C - Chemistry, Metallurgy

07

D

260/237.3

C07D 519/04 (2006.01)

Patent

CA 1114816

X-4956 -1- Abstract of the Disclosure Novel bridged vinca dimers in which two indole-dihydroindole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group are described herein. These compounds are prepared by reacting the corresponding azide of an indole- dihydroindole alkaloid with an appropriate diamine or triamine. The compounds are useful as oncolytic agents.

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