Bridged compounds as hiv integrase inhibitors

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 491/18 (2006.01) A61K 31/55 (2006.01) A61P 31/18 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2750045

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, X3, Y, Z, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

La présente invention concerne les composés de la formule I qui sont des inhibiteurs de l'intégrase du VIH et des inhibiteurs de la réplication du VIH, l'astérisque * dans Q représentant le point d'attache au reste du composé ; et n, L1, L2, X1, X2, ?3, Y, Z, R1, R2 et R3 étant tels que définis dans la description. Les composés sont utiles dans le traitement ou la prévention de l'infection par le VIH et dans le traitement, la prévention ou le retardement de l'apparition ou de la progression du SIDA. Les composés sont utilisés contre l'infection par le VIH et contre le SIDA en tant que composés en soi (ou en tant qu'hydrates ou solvates associés) ou sous la forme de sels pharmaceutiquement acceptables. Les composés et leurs sels peuvent être utilisés en tant qu'ingrédients dans des compositions pharmaceutiques, éventuellement en combinaison avec d'autres antiviraux, immuno-modulateurs, antibiotiques ou vaccins.

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