Bridged element for detection of a target substance

Details Bridged element for detection of a target substance Bridged element for detection of a target substance

G - Physics

01

N

G01N 33/53 (2006.01) C12Q 1/68 (2006.01) G01N 27/49 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) G01N 27/04 (2006.01) G12B 21/02 (2006.01)

Patent

CA 2534632

Physical changes resulting from an association between a template molecule and a target molecule are detected by monitoring changes in the template molecule. Exemplary changes include a change in a physical dimension or stiffness of the template molecule, a change in electrical conductivity of the template molecule and a change in the energy required to dissociate the target molecule and the template molecule. The magnitude of the change is indicative of the specific identity of the target molecule.

Selon l'invention, des changements physiques résultant d'une association entre une molécule matrice et une molécule cible sont détectés par surveillance de changements se produisant dans la molécule matrice. Parmi ces changements, on peut citer : un changement associé à la dimension physique ou à la rigidité de la molécule matrice, un changement associé à la conductivité électrique et un changement associé à l'énergie nécessaire pour dissocier la molécule cible et la molécule matrice. L'amplitude du changement indique l'identité spécifique de la molécule cible.

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