Bridged heterocyclic compounds and methods of use

Details Bridged heterocyclic compounds and methods of use Bridged heterocyclic compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 471/18 (2006.01) A61K 31/4355 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2718790

This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3- b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Cette invention concerne de nouveaux composés qui peuvent être utilisés pour moduler un récepteur à histamine chez un individu. De nouveaux composés sont décrits, comprenant les nouveaux composés de [4,3-b]indole hétérocycliques pontés. Des compositions pharmaceutiques sont également décrites. Des compositions pharmaceutiques contenant les composés selon l'invention sont également décrites ainsi que des procédés d'utilisation des composés dans toute une variété d'applications thérapeutiques, comprenant le traitement d'un trouble cognitif, d'un trouble psychotique, d'un trouble médié par un neurotransmetteur et/ou d'un trouble neuronal.

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