Bridged indoles as matrix metalloprotease inhibitors

Details Bridged indoles as matrix metalloprotease inhibitors Bridged indoles as matrix metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) C07D 487/04 (2006.01) C07D 498/08 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2212236

Compounds of formula (I) as single stereoisomers or mixtures thereof and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as interstitial collagenases, and are useful in the treatment of mammals having disease states alleviated by the inhibition of such matrix metalloproteases, for example arthritic diseases or bone resorption diseases, such as osteoporosis.

L'invention se rapporte à des composés de la formule (I) se présentant sous forme de stéréoisomères uniques ou des mélanges de ceux-ci, ainsi qu'à leurs sels pharmaceutiquement acceptables inhibant les métalloprotéases matricielles, telles que les collagenases interstitielles. Ces composés sont utiles dans le traitement de mammifères présentant des états pathologiques soulagés par l'inhibition de ces métalloprotéases matricielles, telles que des maladies arthritiques ou des maladies relatives à la résorption osseuse telle que l'ostéoporose.

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