Bridged n-bicyclic sulfonamido inhibitors of gamma secretase

C - Chemistry – Metallurgy – 07 – D

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C07D 451/02 (2006.01) A01N 43/00 (2006.01) A01N 43/42 (2006.01) A61K 31/33 (2006.01) A61K 31/44 (2006.01) C07D 487/00 (2006.01) C07D 491/00 (2006.01) C07D 513/00 (2006.01)

Patent

CA 2618087

The invention provides N-bicyclic sulfonamido compounds of Formula (I) wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, such as Alzheimer's disease.

L'invention concerne des composés sulfonamido N-bicycliques représentés par la formule (I) dans laquelle A possède la signification donnée dans le descriptif et R1 et R2 se combinent de manière à former un système cyclique [3.3.1] ou [3.2.1]. Les composés représentés par la formule (I) servent au traitement ou à la prévention de troubles cognitifs tels que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques contenant des composés représentés par la formule (I) ainsi que des procédés de traitement de troubles cognitifs tels que la maladie d'Alzheimer.

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