C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) C07D 451/00 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2453609
Certain novel bridged piperidine derivatives of formula (I): (see formula I) are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of (MC-4R), such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Certains nouveaux dérivés de pipéridine pontée constituent des agonistes du ou des récepteurs humains de la mélanocortine et, en particulier, des agonistes sélectifs du récepteur 4 de la mélanocortine (MC-4R) humain. Ils sont par conséquent utiles pour le traitement de maladies et de troubles réagissant à l'activation du MC-4R, tels que l'obésité, le diabète, les dysfonctionnements sexuels tels que les dysfonctionnements érectiles et les dysfonctionnements sexuels chez la femme, ainsi que pour lutter contre ces maladies et les prévenir.
Barakat Khaled J.
Guo Liangqin
Nargund Ravi P.
Sebhat Iyassu K.
Ye Zhixiong
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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