Bridging antibody fusion constructs

Details Bridging antibody fusion constructs Bridging antibody fusion constructs

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/395 (2006.01) C07K 14/485 (2006.01) C07K 14/73 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2095842

2095842 9208801 PCTABS00013 Disclosed is a bridging antibody construct including a heavy chain variable region which, when combined with a light chain variable region, binds to a surface antigen on an effector cell; a heavy chain constant region comprising a CH3 domain; and a non-immunoglobulin binding agent which binds a surface protein on a target cell. The binding agent is peptide-bonded to the carboxy terminus of said CH3 domain. Also disclosed are a nucleic acid sequence encoding the construct, a cell line transfected with that nucleic acid, a method of producing the construct, and methods of selectively killing a target cell using the construct.

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