A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/44
A61K 39/00 (2006.01) G01N 33/543 (2006.01)
Patent
CA 1089764
ABSTRACT OF THE DISCLOSURE A two-step process for achieving a covalent bond between latex polymers and immunological substances, the first of which involves reacting latex particles having a reactive carboxyl group with a diamine in the presence of an appropriate carbodiimide as the condensing agent. The resulting product, which can be designated as the modified latex, is an amide terminating in primary or secondary amino groups. This product is then reacted with the appropriate immunological reagent such as an antigen or antibody modified if necessary to contain amino groups, in the presence of a bifunctional aldehyde to result in the condensation of the amino groups of the immunological reagent to the amino groups of the modified latex via an intermediate aldehyde bridging moiety.
296191
Harris Joanne L.
Reckel Rudolph P.
Gowling Lafleur Henderson Llp
Ortho Diagnostic Systems Inc.
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