C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A01N 37/18 (2006.01) A01N 43/36 (2006.01) A01N 63/02 (2006.01) A23L 3/3544 (2006.01) A61K 38/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2179286
The present invention provides indolicidin analogs, which are tryptophan-rich peptides that have substantially the same amino acid sequence as naturally occurring indolicidin, exhibit broad spectrum antimicrobial activity and have antimicrobial selectivity as compared to naturally occurring indolicidin. The invention also provides methods of using an indolicidin analog to inhibit or prevent the survival or growth of a microorganism in an environment capable of sustaining such survival or growth. The invention provides, for example, methods of administering ar effective amount of an indolicidin analog to an environment capable of sustaining the survival or growth of a microorganism.
L'invention porte sur des analogues de l'indolicidine qui sont peptides riches en trytophane présentant sensiblement la même séquence aminoacide que l'indolicidine naturelle, et présentent une activité antimicrobienne à large spectre et une sélectivité antimicrobienne supérieure à celle de l'indolicidine naturelle. L'invention porte également sur leur mode d'utilisation pour prévenir ou inhiber la survie ou la croissance de micro-organismes dans un environnement favorisant la survie ou la croissance de ces derniers, et notamment, sur des modes d'administration d'une dose efficace d'un analogue de l'indolicidine à un environnement favorisant la survie ou la croissance de micro-organismes.
Smart & Biggar
The Regents Of The University Of California
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