C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2159085
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate hostcells. The protein is a second in-frame AUG codon-initiated retinoblasoma protein of about 94 kD relative molecular mass. The present invention also relates to methods of treating a mammal having a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer and methods of treating abnormally proliferating cells, such as tumor or cancer cells. Treatment is accomplished by inserting a host cell compatible p94RB expression vector or an effective amount of p94RB protein into a cell or cells in need of treatment.
Benedict William F.
Xu Hong-Ji
Xu Shi-Xue
Baylor College Of Medicine
Osler Hoskin & Harcourt Llp
LandOfFree
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