Brominated hexahydroxybiphenyl derivatives

Details Brominated hexahydroxybiphenyl derivatives Brominated hexahydroxybiphenyl derivatives

C - Chemistry, Metallurgy

07

D

C07D 317/62 (2006.01) A61K 31/36 (2006.01) A61K 31/40 (2006.01) A61K 31/495 (2006.01) C07D 317/68 (2006.01)

Patent

CA 2223898

Derivatives of 4,4'-dimethoxy-5,6,5',6'-bimethylenedioxy-2,2'- dimethoxycarbonyl biphenyl (DDB) were synthesized and found to have anti-HIV activity. Of the compounds studied, 3,3'-dibromo DDB and 3-bromo- DDB initially exhibited the greatest anti-HIV activity.

On a synthétisé des dérivés de 4,4'-diméthoxy-5,6,5',6'-biméthylènedioxy-2,2'-diméthoxycarbonyle biphényle (DDB) et on a découvert que ces dérivés ont une activité anti-VIH. Parmi les composés étudiés, le 3,3'-dibromo DDB et le 3-bromo-DDB présentent initialement l'activité anti-VIH la plus importante.

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