C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/33 (2006.01) A61K 31/365 (2006.01) C07K 14/195 (2006.01) C12N 1/20 (2006.01) C12N 15/52 (2006.01) C12P 19/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2381290
The present invention recognizes that marine organisms comprise nucleic acid molecules that encode polypeptides that catalyze the synthesis of bioactive compounds, such as polyketides including bryopyran rings, such as bryostatins. One aspect of the present invention is a composition including at least one nucleic acid molecule that encodes at least one polypeptide that catalyzes at least one step in the synthesis of at least one polyketide such as a bryopyran ring, wherein said at least one nucleic acid molecule is derived from at least one marine organism. A second aspect of the present invention is a composition including a library of nucleic acid molecules of the present invention. These nucleic acid molecules can be used in a combinatorial biosynthesis of polyketides, bryopyran rings and bryostatins.
La présente invention concerne des organismes marins comprenant des molécules d'acide nucléique codant pour des polypeptides qui catalysent la synthèse de composés bioactifs, tels que des polyketides, y compris des anneaux de bryopyranne, comme les bryostatines. La présente invention concerne, d'une part, une composition comprenant au moins une molécule d'acide nucléique codant pour au moins un polypeptide catalysant au moins une étape de la synthèse d'au moins un polyketide tel qu'un anneau de bryopyranne, ladite molécule d'acide nucléique étant dérivée d'au moins un organisme marin. La présente invention concerne, d'autre part, une composition comprenant une bibliothèque de molécules d'acide nucléique. Ces molécules d'acide nucléique peuvent être utilisées dans une biosynthèse combinatoire de polyketides, d'anneaux de bryopyranne et de bryostatines.
Allen Scott W.
Davidson Seana K.
Haygood Margo
Hildebrand Mark
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
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