Btl-ii nucleic acids, proteins, and antibodies

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 37/00 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 1/02 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2509999

The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.

L'invention concerne des protéines, des acides nucléiques, des anticorps, des antagonistes, et des agonistes BTL-II isolés, ainsi que des méthodes de mise au point et d'utilisation de ceux-ci. L'invention concerne également des méthodes de diagnostic, de criblage, et de traitement dans lesquelles sont utilisées les compositions de l'invention. Les compositions de l'invention peuvent être utilisées, par exemple, dans le diagnostic et le traitement des maladies inflammatoires de l'intestin, ainsi que pour améliorer la réponse immune des muqueuses à un antigène.

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