Buccal administration of estrogens

Details Buccal administration of estrogens Buccal administration of estrogens

A - Human Necessities

61

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167/198

A61K 31/565 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 1306950

ABSTRACT OF THE DISCLOSURE An adequate blood plasma level of 17-beta-estradiol or ethinyl estradiol is attained in a patient in need of estrogen therapy by administration of a dose of 17-beta-estradiol or ethinyl estradiol or a pharmaceutically acceptable ester thereof not greater than 150 micrograms into the vestibule of the buccal cavity of the patient and maintaining the dose in contact with the oral mucosa for a period of time sufficient for transmucosal absorption of a sufficient amount of estrogen to produce a therapeutically effective plasma concentration of estrogen.

563490

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