Buccal application system comprising 17a-estradiol

Details Buccal application system comprising 17a-estradiol Buccal application system comprising 17a-estradiol

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/565 (2006.01) A61P 15/12 (2006.01)

Patent

CA 2751399

The invention relates to application systems for buccal application, comprising l7.alpha.- estradiol in a dosage of 50 to 400 µg, preferably 200 to 400 µg, particularly preferably 300 µg, together with one or more pharmaceutically acceptable additives or media for implementing the treatment or minimization of hot flashes in women having estrogen deficiencies.

L'invention porte sur des systèmes d'administration buccale, contenant du 17a-oestradiol à une dose de 50 à 400 µg, de préférence de 200 à 400 µg, d'une manière particulièrement préférée de 300 µg, en même temps qu'un ou plusieurs adjuvants/supports pharmaceutiquement acceptables, ces systèmes réalisant un traitement/une réduction minimum des bouffées de chaleur chez les femmes présentant des phénomènes de carence en strogènes.

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