Buccal delivery of glucagon-like insulinotropic peptides

Details Buccal delivery of glucagon-like insulinotropic peptides Buccal delivery of glucagon-like insulinotropic peptides

A - Human Necessities

61

K

A61K 38/26 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2235369

Drug delivery systems and methods for administering a glucagon-like insulinotropic peptide to the buccal mucosa for transmucosal drug delivery are described. The drug delivery systems comprise a drug composition containing an effective amount of the glucagon-like insulinotropic peptide and an effective amount of a permeation enhancer for enhancing permeation of glucagon-like insulinotropic peptide through the buccal mucosa and means for maintaining the drug composition in a drug transferring relationship with buccal mucosa. These systems can be in free form, such as creams, gels, and ointments, or can comprise a device of determined physical form, such as tablets, patches, and troches. A preferred glucagon-like insulinotropic peptide is GLP-1(7-36)amide.

Systèmes d'apport de médicament et procédés d'administration d'un peptide insulinotropique du type glucagon sur la muqueuse buccale pour apporter le médicament à travers la muqueuse. Les systèmes d'apport de médicament comprennent une composition de médicament contenant une quantité efficace du peptide insulinotropique du type glucagon et une quantité efficace d'une accélération de pénétration qui permet d'améliorer la pénétration du peptide insulinotropique du type glucagon à travers la muqueuse buccale et un système permettant de maintenir la composition du médicament afin d'assurer le transfert du médicament à travers la muqueuse buccale. Les systèmes peuvent se présenter sous forme de crèmes, de gels ou d'onguents ou bien sous une forme solide telle que des comprimés, des patches ou des pastilles. Un peptide insulinotropique du type glucagon préféré est le GLP-1(7-36)amide.

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