Buccal delivery system for proteinaceous medicaments

Details Buccal delivery system for proteinaceous medicaments Buccal delivery system for proteinaceous medicaments

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 9/12 (2006.01) A61K 38/17 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2361262

A delivery formulation and system for delivering proteinaceous medicaments such as inactivated bioactive peptides to the body. The formulation includes effective amounts of the peptide as well as a tissue (e.g., mucosal) permeation enchancer selected from the group consisting of quaternary ammonium salts. The system can be used, for instance, by spraying the formulation into the buccal cavity, e.g., to the roof of the mouth.

La présente invention concerne une formulation et un système d'administration de médicaments protéiniques dans le corps, tels que des peptides bioactifs inactivés. La formulation comprend des quantités efficaces de peptide ainsi qu'un stimulateur de perméation de tissu (par exemple des muqueuses) sélectionné dans le groupe formé de sels d'ammonium quaternaire. Le système peut s'utiliser, entre autres, par pulvérisation de la formulation dans la cavité buccale, par exemple sur le plafond de la cavité buccale.

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