Buccal drug delivery

Details Buccal drug delivery Buccal drug delivery

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/22 (2006.01)

Patent

CA 2537797

A lozenge is provided that has stable pH and stable levels of active ingredient over time. It comprises a combination of (i) at least one gum and (ii) at least one non-crystallising sugar or non-crystallising sugar alcohol in a matrix designed for controlled buccal delivery of a drug. The lozenge also contains water and optional components selected from flavourings, taste masking agents, colourings, buffer components, pH adjusting agents, excipients, stabilizers and sweeteners. Methods ofpreparing the lozenge are also provided.

L'invention concerne une pastille présentant un pH stable et des niveaux stables de principe actif au fil du temps. La pastille selon l'invention comprend une association de: (i) au moins une gomme, et; (ii) au moins un sucre non cristallisable ou un alcool de sucre non cristallisable dans une matrice pour permettre l'administration régulée d'un médicament par voie orale. Ladite pastille contient également de l'eau et éventuellement des composants sélectionnés parmi les éléments suivants: des aromatisants, des agents masquant le goût, des colorants, des composants tampons, des agents de régulation de pH, des excipients, des stabilisateurs et des édulcorants. La présente invention se rapporte en outre à des procédés pour préparer ladite pastille.

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