Buccal, non-polar spray for nitroglycerin

Details Buccal, non-polar spray for nitroglycerin Buccal, non-polar spray for nitroglycerin

A - Human Necessities

61

K

A61K 31/21 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2251564

A buccal aerosol spray using a non-polar solvent has now been developed which provides nitroglycerin for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal aerosol spray of the invention comprises: propellant 50-95%, non-polar solvent 5- 50%, nitro- glycerin 0.001-15%, flavoring agent 0.05-5%.

L'invention concerne un pulvérisateur d'aérosols buccal, utilisant un solvant non polaire. Ce pulvérisateur fournit de la nitroglycérine en vue de son absorption rapide par les muqueuses buccales, ce qui permet d'obtenir un effet très rapide. Le pulvérisateur selon l'invention comprend 50 - 95 % d'un agent propulseur, 5 - 50 % de solvant non polaire, 0,001 - 15 % de nitroglycérine, 0,05 - 5 % d'un agent aromatisant.

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