Buccal, non-polar spray or capsule

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/12 (2006.01) A61K 9/00 (2006.01) A61K 9/48 (2006.01) A61K 31/40 (2006.01) A61K 31/465 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2252050

A buccal aerosol spray or capsule using a non-polar solvent has now been developed which provides biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal aerosol spray of the invention comprises formulation (I): propellant 50-95 %, non-polar solvent 5-50 %, active compound 0.0025- 40 %, flavoring agent 0.05-5 %. The soft bite gelatin capsule of the invention comprises formulation (II): non-polar solvent 30-99.8 %, emulsifier 0-20 %, active compound 0.0003-32 %, and flavoring agent 0.05-60.

L'invention concerne un pulvérisateur ou une capsule d'aérosols buccal utilisant un solvant non polaire. Ce pulvérisateur ou cette capsule fournissent des composés biologiquement actifs en vue de leur absorption rapide par les muqueuses buccales, ce qui permet d'obtenir un effet très rapidement. Le pulvérisateur d'aérosols buccal selon l'invention comprend la formulation (I), à savoir, 50 à 95 % de gaz propulseur, 5-50 % de solvant non polaire, 0,001-15 % d'un composé actif, 0,05-5 % d'un agent aromatisant. La capsule de gélatine molle selon l'invention comprend la formulation (II) à savoir, 55-99,8 % d'un solvant non polaire, 0-20 % d'émulsifiant, 0,001-25 % de composé actif, et 0,05-5,0 % d'un agent aromatisant.

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