Buccal, polar and non-polar spray containing alprazolam

Details Buccal, polar and non-polar spray containing alprazolam Buccal, polar and non-polar spray containing alprazolam

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2581996

Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide alprazolam for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation (I): aqueous polar solvent, alprazolam, and optional flavoring agent; formulation (II): aqueous polar solvent, alprazolam, optionally flavoring agent, and propellant; formulation (III): non-polar solvent, alprazolam, and optional flavoring agent; formulation (IV): non-polar solvent, alprazolam, optional flavoring agent, and propellant; formulation (V): a mixture of a polar solvent and a non-polar solvent, alprazolam, and optional flavoring agent; formulation (VI): a mixture of a polar solvent and a non-polar solvent, alprazolam, optional flavoring agent, and propellant.

L'invention porte sur des capsules ou sur des pulvérisateurs aérosol buccaux utilisant des solvants polaires et non polaires qui contiennent de l'alprazolam pour une absorption rapide dans les muqueuses buccales et dont les effets sont rapides. Les compositions polaires buccales de l'invention comprennent la formulation (I): solvant polaire aqueux, alprazolam et agent aromatique éventuel; la formulation (II): solvant polaire aqueux, alprazolam, avant aromatique éventuel et propulseur; la formulation (III): solvant non polaire, alprazolam et agent aromatique éventuel; la formulation (IV): solvant non polaire, alprazolam, agent aromatique éventuel et propulseur; la formulation (V): un mélange d'un solvant polaire et d'un solvant non polaire, alprazolam et un agent aromatique éventuel; la formulation (VI): un mélange d'un solvant polaire et d'un solvant non plaire, alprazolam, un agent aromatique éventuel et un propulseur.

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