Buccal, polar and non-polar spray containing sumatriptan

Details Buccal, polar and non-polar spray containing sumatriptan Buccal, polar and non-polar spray containing sumatriptan

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/40 (2006.01) A61K 31/4045 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2582008

Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide sumatriptan for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, sumatriptan, and optional flavoring agent; formulation II: aqueous polar solvent, sumatriptan, optionally flavoring agent, and propellant; formulation III: non-polar solvent, sumatriptan, and optional flavoring agent; formulation IV: non-polar solvent, sumatriptan, optional flavoring agent, and propellant; formulation V: a mixture of a polar solvent and a non-polar solvent, sumatriptan, and optional flavoring agent; formulation VI: a mixture of a polar solvent and a non-polar solvent, sumatriptan, optional flavoring agent, and propellant.

On a mis au point des sprays buccaux ou des capsules buccales au moyen de solvants polaire et non polaire, sprays fournissant du sumatriptan destiné à être absorbé rapidement par la muqueuse orale, et produisant ainsi un effet rapide. Les compositions polaires buccales de l'invention comprennent la formule I: solvant polaire aqueux, sumatriptan et aromatisant éventuel; formule II: solvant polaire aqueux, sumatriptan, aromatisant éventuel et propulseur; formule III: solvant non polaire, sumatriptan, aromatisant éventuel; formule IV: solvant non polaire, sumatriptan, aromatisant éventuel et propulseur; formule V: mélange d'un solvant polaire et d'un solvant non polaire, de sumatriptan et d'aromatisant éventuel; formule VI: un mélange d'un solvant polaire et d'un solvant non polaire, sumatriptan, aromatisant éventuel et propulseur.

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