Buccal, polar and non-polar spray containing zolpidem

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/12 (2006.01) A61K 9/40 (2006.01) A61K 31/437 (2006.01) A61P 25/20 (2006.01)

Patent

CA 2582018

Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide zolpidem for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation aqueous polar solvent, zolpidem, and optional flavoring agent; formulation II: aqueous polar solvent, zolpidem, optionally flavoring agent, and propellant; formulation III: non-polar solvent, zolpidem, and optional flavoring agent; formulation IV: non-polar solvent, zolpidem, optional flavoring agent, and propellant; formulation V: a mixture of a polar solvent and a non-polar solvent, zolpidem, and optional flavoring agent; formulation VI: a mixture of a polar solvent and a non-polar solvent, zolpidem, optional flavoring agent, and propellant.

Il existe maintenant des aérosols oraux ou des capsules avec solvants polaires ou non polaires pour l'administration de zolpidem, l'absorption rapide par la muqueuse buccale entraînant un déclenchement rapide de l'effet recherché. Les compositions polaires orales de l'invention existent en diverses formulations. Formulation I: solvant polaire aqueux, zolpidem, et éventuellement agent aromatisant; formulation II: solvant polaire aqueux, zolpidem, éventuellement agent aromatisant, et agent propulseur; formulation III: solvant non polaire, zolpidem, éventuellement agent aromatisant; formulation IV: solvant non polaire, zolpidem, éventuellement agent aromatisant, et agent propulseur; formulation V: mélange de solvant polaire et de solvant non polaire, zolpidem, et éventuellement agent aromatisant; formulation VI: mélange de solvant polaire et de solvant non polaire, zolpidem, éventuellement agent aromatisant, et agent propulseur.

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