Buccal, polar and non-polar spray or capsule

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/48 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2306024

Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprises formulation I: aqueous polar solvent 30-99.89%, active compound 0.001-60%, optionally containing flavoring agent 0.1-10%. The non polar composition of the invention comprises formulation II: non-polar solvent 20-85%, active compound 0.005-50%, and optionally flavoring agent 0.1-10% and propellant 50-80%.

On a, à ce jour, mis au point des aérosols ou des gélules buccaux utilisant un solvant polaire et non polaire, lesquels constituent des composés biologiquement actifs destinés à une absorption rapide à travers la muqueuse orale, se traduisant par le déclenchement rapide de l'effet. Les compositions buccales polaires de l'invention comprennent la formulation (I) constituée de 30 à 99,89 % d'un solvant aqueux polaire, de 0,001 à 60 % d'un composé actif, contenant facultativement 0,1 à 10 % d'un agent aromatisant. La composition non polaire de l'invention comprend une formulation (II) renfermant 20 à 85 % d'un solvant non polaire, 0,005 à 50 % d'un composé actif et facultativement 0,1 à 10 % d'un agent aromatisant ainsi que 50 à 80 % d'un gaz propulseur.

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