Buccal, polar and non-polar sprays containing propofol

Details Buccal, polar and non-polar sprays containing propofol Buccal, polar and non-polar sprays containing propofol

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61F 13/02 (2006.01) A61K 9/72 (2006.01) A61K 31/19 (2006.01)

Patent

CA 2582265

Buccal aerosol sprays using polar and/or non-polar solvents have now been developed which provide propofol for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: propofol, a polar solvent and an optional flavoring agent; formulation II: propofol, a polar solvent, a propellant, and an optionally flavoring agent; formulation III: propofol, a non-polar solvent, and an optional flavoring agent; formulation IV: propofol, a non-polar solvent, a propellant, and an optional flavoring agent; formulation V: propofol, a mixture of a polar solvent and a non-polar solvent, and an optional flavoring agent; and formulation VI: propofol, a mixture of a polar solvent and a non-polar solvent, a propellant, and an optional flavoring agent.

La présente invention se rapporte à des pulvérisateurs d'aérosol buccaux utilisant des solvants polaires et des solvants non polaires, qui permettent de délivrer du propofol de sorte que celui-ci soit absorbé rapidement par la muqueuse orale, ceci permettant de déclencher rapidement un effet. Ces compositions polaires buccales de l'invention comportent la formulation I: du propofol, un solvant polaire et un agent aromatisant facultatif; la formulation II: du propofol, un solvant polaire, un agent propulseur et un agent aromatisant facultatif; la formulation III: du propofol, un solvant non polaire, et un agent aromatisant facultatif; la formulation IV: du propofol, un solvant non polaire, un agent propulseur, et un agent aromatisant facultatif; la formulation V: du propofol, un mélange d'un solvant polaire et d'un solvant non polaire, et un agent aromatisant facultatif; et la formulation VI: du propofol, un mélange d'un solvant polaire et d'un solvant non polaire, un agent propulseur et un agent aromatisant facultatif.

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