Buffer solutions having selective bactericidal activity...

Details Buffer solutions having selective bactericidal activity... Buffer solutions having selective bactericidal activity...

A - Human Necessities

61

K

A61K 47/18 (2006.01) A61K 31/5575 (2006.01)

Patent

CA 2698721

Buffer solutions for pharmaceutical preparations that have bactericidal activity preferentially against gram negative bacteria are provided. The buffers have a pH of greater than about 10 or less than about 4.5 with low buffer capacity. Methods of their use in reducing the occurrence of blood stream infections in a mammal is also provided.

La présente invention a trait à des solutions tampons pour préparations pharmaceutiques présentant une activité bactéricide préférentiellement dirigée contre les bactéries à gram négatif. Ces tampons ont un pH supérieur à environ 10 ou inférieur à environ 4,5 et sont caractérisés par une faible capacité tampon. L'invention concerne également leurs procédés d'utilisation à des fins de réduction de la survenue d'infections transmises par voie sanguine chez un mammifère.

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