Buffered resorbable internal fixation devices and methods...

Details Buffered resorbable internal fixation devices and methods... Buffered resorbable internal fixation devices and methods...

A - Human Necessities

61

L

A61L 31/14 (2006.01) A61B 17/86 (2006.01) A61L 31/02 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2345773

An internal fixation device and a bioerodible implantable material useful therefor comprise a bioerodible polymer that produces acidic products or low molecular weight resorbable fragments upon hydrolytic degradation, and a buffering or neutralizing agent in sufficiently high concentration to moderate the rate of change of pH of said bioerodibie material during bioerosion. The buffering or neutralizing agent acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Internal fixation devices (IFDs) according to the invention are useful, for example, for the repair, replacement or reconstruction of damaged bone in any area of the body.

L'invention concerne un dispositif de fixation interne et un matériau implantable et bio-érodable associé, comprenant un polymère bio-érodable qui produit des constituants acides ou des fragments de masse moléculaire faible, pouvant se résorber par dégradation hydrolytique, et un agent tampon ou neutralisant d'une concentration suffisamment élevée pour modérer la vitesse de modification du pH du matériau bio-érodable pendant la bio-érosion. L'action de l'agent tampon ou neutralisant permet de réduire la réaction inflammatoire du corps étranger générée par les constituants acides, ainsi que l'état d'abcès stérile survenant sur le site des matériaux implantés bio-érodables des techniques antérieures. Les dispositifs de fixation internes peuvent être utilisés, par exemple, dans une réparation, un remplacement ou une reconstruction d'os endommagés dans n'importe quelle partie du corps.

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