Bumetanide, furosemide, piretanide, azosemide, and torsemide...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 307/34 (2006.01) A61K 31/4355 (2006.01) A61P 25/28 (2006.01) C07D 307/52 (2006.01)

Patent

CA 2750339

The present invention provides bumetanide, furosemide, piretanide, azosemide, and torsemide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide, furosemide, piretanide, azosemide, and torsemide analogs and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl- co-transporter or GABA A receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, insomnia, ischemia, migraine, migraine with aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

La présente invention concerne des analogues de bumétanide, de furosémide, de pirétanide, d'azosémide et de torsémide, ainsi que des compositions comprenant lesdits analogues. La présente invention concerne également des compositions pharmaceutiques contenant ces analogues de bumétanide, de furosémide, de pirétanide, d'azosémide et de torsémide, ainsi que des procédés d'utilisations de ceux-ci. Tous ces analogues sont particulièrement utiles dans le traitement et/ou la prophylaxie d'états qui impliquent le co-transporteur Na+K+Cl- ou le récepteur GABAA, tels que, mais non exclusivement, les troubles de l'addiction, la maladie d'Alzheimer, les troubles de l'anxiété, les ascites, l'autisme, les troubles bipolaires, le cancer, la dépression, la dystrophie cornéenne endothéliale, l'dème, l'épilepsie, le glaucome, la maladie d'Huntington, l'insomnie, l'ischémie, la migraine, la migraine avec aura, les douleurs neuropathiques, les névralgies nociceptives, les douleurs nociceptives, les maladies oculaires, la douleur, la maladie de Parkinson, les troubles de la personnalité, les névralgies postherpétiques, les psychoses, la schizophrénie, les crises, les acouphènes, et les syndromes de sevrage.

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