Buprenorphine derivatives and uses thereof

Details Buprenorphine derivatives and uses thereof Buprenorphine derivatives and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 498/12 (2006.01) A61K 31/485 (2006.01) A61P 25/36 (2006.01)

Patent

CA 2647417

Ester derivatives of the phenolic hydroxyl group of buprenorphine are described that can be used in the treatment of opiate dependency and/or moderate to severe pain. The esters have an enhanced bioavailability, an enhanced duration of action, and a reduced abuse potential.

L'invention concerne des dérivés ester du groupe hydroxyle phénolique de la buprénorphine pouvant être utilisés dans le traitement de la dépendance aux opiacés et/ou de la douleur moyenne à aiguë. Les esters ont une biodisponibilité accrue, une durée d'action accrue et un potentiel d'abus réduit.

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