Bupropion metabolites and methods of their synthesis and use

Details Bupropion metabolites and methods of their synthesis and use Bupropion metabolites and methods of their synthesis and use

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2400482

Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, sexual dysfunction, affective disorders, cerebral function disorders, cigarette smoking, and incontinence. Methods of making optically pure bupropion metabolites are also disclosed.

L'invention concerne des procédés et des compositions qui utilisent des métabolites du bupropion pour traiter des troubles que l'on atténue par l'inhibition de la réabsorption neuronale des monoamines. De tels troubles sont notamment : les dysfonctionnement sexuels, les troubles affectifs, les troubles des fonctions cérébrales, l'usage du tabac et l'incontinence. L'invention concerne également des procédés de fabrication de métabolites du bupropion optiquement purs.

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