Bupropion metabolites and methods of their synthesis and use

Details Bupropion metabolites and methods of their synthesis and use Bupropion metabolites and methods of their synthesis and use

C - Chemistry, Metallurgy

07

D

C07D 265/32 (2006.01) A61K 31/00 (2006.01) A61K 31/133 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/165 (2006.01) A61K 31/415 (2006.01) A61K 31/43 (2006.01) A61K 31/435 (2006.01) A61K 31/46 (2006.01) A61K 31/465 (2006.01) A61K 31/50 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/5375 (2006.01) A61K 45/06 (2006.01) C07C 49/76 (2006.01) C07C 49/807 (2006.01) C07C 49/82 (2006.01) C07C 49/84 (2006.01) C07C 213/00 (2006.01) C07C 215/30 (2006.01) C07C 225/16 (2006.01) C07C 317/14 (2

Patent

CA 2362361

Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affective disorders, cerebral function disorders, cigarette smoking, and incontinence. The invention further discloses methods of making optically pure bupropion metabolites.

L'invention concerne des procédés et compositions qui utilisent des métabolites du bupropion pour traiter des troubles améliorés par inhibition de réabsorption de monoamines neuronales. De tels troubles sont notamment: troubles de l'érection, troubles affectifs, troubles des fonctions cérébrales, usage du tabac et incontinence. L'invention concerne également des procédés de fabrication de métabolites du bupropion optiquement purs.

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