Burst drug release compositions

Details Burst drug release compositions Burst drug release compositions

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2761795

A solid dose composition comprising at least one pharmaceutically active ingredient and at least one controlled release agent and method of manufacturing said composition is disclosed. The burst profile of at least one pharmaceutically active ingredient in the composition is regulated by the apparent viscosity of the controlled release agent and wherein at least one pharmaceutically active ingredient is processed by wet granulation.

L'invention porte sur une composition en dose solide comprenant au moins un ingrédient pharmaceutiquement actif et au moins un agent à libération contrôlée et sur un procédé de fabrication de ladite composition. Le profil en rafale d'au moins un ingrédient pharmaceutiquement actif dans la composition est régulé par la viscosité apparente de l'agent à libération contrôlée, au moins un ingrédient pharmaceutiquement actif étant traité par granulation par voie humide.

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