Butadiene derivatives and process for preparing the same

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 235/78 (2006.01) A61K 31/215 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) C07C 69/734 (2006.01) C07D 207/444 (2006.01) C07D 213/56 (2006.01) C07D 295/145 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2092017

41 ABSTRACT OF THE DISCLOSURE: Novel butadiene derivatives of the formula [1]: Image [I] wherein Ring A is tri-lower alkoxyphenyl, R1 and R2 combine each other to form a group of the formula: Image or one of R1 and R2 is lower alkoxy, and the other is group of the formula: -NHR3, in which R3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.

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