Butenafine hydrochloride-containing aqueous patch

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/137 (2006.01) A61K 9/70 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2719364

Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.

La présente invention concerne un timbre transdermique adhésif à base d'eau ayant une excellente stabilité en stockage et permettant d'obtenir une excellente accumulation du chlorhydrate de buténafine qu'il contient sur une zone, par exemple de peau et d'ongle, recouverte par le timbre, et ayant un effet thérapeutique élevé. La présente invention concerne, plus précisément, un timbre transdermique adhésif à base d'eau contenant du chlorhydrate de buténafine, qui se caractérise en ce qu'il contient du chlorhydrate de buténafine, du salicylate de glycol et du propylèneglycol dans un onguent en gel contenant de l'eau. Plus précisément, le chlorhydrate de buténafine est dissous dans une solution mixte de salicylate de glycol et de propylèneglycol ; la solution obtenue est dispersée dans un gel contenant de l'eau. Plus précisément, le rapport du mélange entre le salicylate de glycol et le propylèneglycol est compris entre 1:2 et 1:30.

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