C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/252, 167/260
C07C 235/78 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) B01J 19/12 (2006.01) C07C 233/12 (2006.01)
Patent
CA 1328277
Abstract The present invention relates to novel compounds of the general formula (I), Image (I) wherein R stands for hydrogen, halogen, C1-4alkyl, C1-4alkoxy or C1-4acylamino group; R1 means hydrogen or a carboxyl-protective group; and R2 represents a -(CH2)n-CO2R5 group, wherein n is 1, 2, 3 or 4; and R5 stands for hydrogen or a carboxyl-protective group; or R2 means a -(CH2)n-NH2 group, wherein n is 1, 2, 3 or 4 of E and/or Z configuration as well as their salts. The compounds according to the invention show a cytoprotective effect and promote the healing of the stomach ulcer. Their toxicity is low.
578345
Dobay Laszlo
Ezer Elemer
Fischer Janos
Fodor Tamas
Matuz Judit
Marks & Clerk
Richter Gedeon Vegyeszeti Gyar Rt
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