Butyne diol derivatives

Details Butyne diol derivatives Butyne diol derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) A61K 31/505 (2006.01) C07D 213/00 (2006.01) C07D 239/00 (2006.01) C07D 239/34 (2006.01) C07D 239/46 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2389479

The present invention relates to novel butyne diol derivatives ofgeneral formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the general formula (I) and especially their use as endothelin receptor antagonists.

L'invention concerne de nouveaux dérivés de butynediol représentés par la formule générale (I) ainsi que l'utilisation de ceux-ci en tant qu'ingrédient actif pour la préparation de compositions pharmaceutiques. L'invention porte également sur des aspects connexes, notamment des procédés permettant de préparer ces composés, des compositions pharmaceutiques contenant un ou plusieurs composés répondant à la formule générale (I), et en particulier l'utilisation de ceux-ci en tant qu'antagonistes de l'endothéline.

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