Butyrophenone transdermal compositions

Details Butyrophenone transdermal compositions Butyrophenone transdermal compositions

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61K 9/70 (2006.01) A61K 31/12 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2121991

ABSTRACT OF THE DISCLOSURE A butyrophenone transdermal composition which comprises the following components (a) to (f): (a) a water-soluble polymer which is constituted by a monomer containing, partly or wholly, aliphatic carboxylic acid having a polymerizable double bond or a salt of the carboxylic acid, (b) a cross linking agent, (c) a cross linking promoter, (d) water, (e) a butyrophenone drug, and (f) a solvent for the butyrophenone drug (e), as essential components. The pH of the composition is adjusted to fall in the range of 5.5 to 8Ø With the composition of the invention, the concentration of the active component butyrophenone in blood can be controlled. The composition is capable of exhibiting its primary action, antiemetic action, without causing rash in the skin and with less adverse side effects.

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